| Date | Location | Result | |
| Nov 20, 2021 | Richmond, Ky. | Eastern Kentucky 39, Jacksonville State 31 | Box score |
| Nov 13, 2021 | Beaumont, Texas | Jacksonville State 38, Lamar University 7 | Box score |
| Nov 06, 2021 | Jacksonville, Alabam | Jacksonville State 40, Abilene Christian 25 | Box score |
| Oct 30, 2021 | Jacksonville, Alabam | Central Ark. 38, Jacksonville State 14 | Box score |
| Oct 23, 2021 | Huntsville, Texas | Sam Houston 42, Jacksonville State 7 | Box score |
| Oct 09, 2021 | Jacksonville, Alabam | Jacksonville State 28, SFA 24 | Box score |
| Oct 02, 2021 | Kennesaw, Georgia | Kennesaw St. 31, Jacksonville State 6 | Box score |
| Sep 25, 2021 | Jacksonville, Alabam | UT Martin 34, Jacksonville State 31 | Box score |
| Sep 18, 2021 | Jacksonville, Alabam | Jacksonville State 27, North Ala. 24 | Box score |
| Sep 11, 2021 | Tallahassee, Florida | Jacksonville State 20, Florida St. 17 | Box score |
| Sep 01, 2021 | Montgomery, Alabama | UAB 31, Jacksonville State 0 | Box score |